Luteolin is a flavonoid and an antioxidant that is present in fruits and vegetables, including broccoli, carrots, and celery. Early research suggests that luteolin supports male testosterone levels by blocking the female sex hormone, estrogen. (1, 2, 3)

As a potent hormone regulator, luteolin can help delay symptoms of “andropause,” a condition that reduces men’s testosterone levels as they age. As such, luteolin offers you a range of benefits associated with higher T levels, including:

Physical Benefits

  • Provides antioxidants for cell protection and healthy aging
  • Increases energy and libido
  • Helps with fat loss
  • Improves performance
  • Reduces inflammation
  • Speeds up the recovery from training and injuries

Mental Benefits

  • Balances mood
  • Promotes brain blood flow for more mental clarity
  • Improves confidence
  • Protects brain cells and nerves
  • Supports neuron growth in the hippocampus

How Luteolin Works

As luteolin is present in many plants and herbs, it serves to protect them from microbes and other environmental threats.

For us, luteolin can provide a range of health benefits. This includes increased blood flow, protection from free radicals and cancer, neurogenesis, enhanced vitality & strength, and even improved resistance to emotional stress. (4, 5, 6, 7, 8)

Why Luteolin?

Centrapeak uses luteolin due to its unique ability to recharge testosterone but also support your mental well-being.

In the body, luteolin plays two important roles in regulating your hormonal balance and brain health:

  1. Luteolin helps your body maintain a healthy ratio of testosterone and estrogen. It achieves this by reducing the conversion of the male hormone to the female sex hormone. As such, it acts as an indirect testosterone booster. Luteolin is also shown to speed up the metabolism of carbohydrates, helping you to stay lean and healthy. (1, 2, 3, 9, 10, 11)
  2. Luteolin protects brain cells and increases feel-good neurotransmitters. Luteolin is shown to boost GABA, a brain chemical that calms the nerves and improves mood. To put this into perspective, GABA is responsible for that ‘buzz’ you’d get after drinking a beer. (12, 13, 14)

You’ll find luteolin in many foods, but also herbs. The Chinese were first to discover that among 1431 natural compounds they tested, luteolin was the king at reducing estrogen levels.

Interesting fact: Luteolin was first discovered in 1938, by a Hungarian biochemist Albert Szent-Györgyi. Initially it was named vitamin P and was found to belong to the flavonoid family.

Centrapeak’s Premium Luteolin

  • Delivered in eco-friendly pullulan capsules made from fermented tapioca, which enhances absorption
  • cGMP certified
  • Highly effective dose of 50mg per serving

How Luteolin Benefits Your Testosterone

Luteolin can be particularly beneficial for men experiencing testosterone decline, be it from aging, stress, or other factors. Luteolin keeps testosterone in a more youthful range by balancing estrogen levels.

However, the way in which luteolin raises testosterone and reduces estrogen is rather surprising.

  • Instead of directly affecting your hormones, luteolin blocks the aromatase enzyme, which turns your testosterone to estrogen. (1, 2, 3)

Research has shown that luteolin is able to inhibit aromatase even before it’s synthesized. Luteolin blocks enzymes such as cAMP and PDE4, which help create more of the aromatase enzyme.

Using luteolin to inhibit this process helps to keep your estrogen levels from shooting up, while giving your testosterone more room to breathe.

The result?

You’ll feel better and more energized, with increased confidence to see your personal goals through.

Luteolin & Brain Health

As luteolin is a potent flavonoid, it protects the brain from inflammation and oxidative stress. Specifically, luteolin improves brain health via the following actions (6, 15, 16, 17, 18):

  1. Reduces glutamate. Glutamate is an excitatory neurotransmitter that increases the firing between your brain cells. The issue is, too much glutamate can overexcite your brain cells to destruction. Luteolin is shown to help reduce glutamate brain levels.
  2. Combats depression & improves your mood. Not only does luteolin protect the brain from too much glutamate, it also directly shields your nerve cells in the hippocampus from inflammation. The area of the brain known to regulate mood, memory, and other cognitive functions. Luteolin also interacts with GABA, a hormone that reduces anxiety and improves your feelings of well-being.
  3. Blocks protein mutations. Due to oxidative stress and other factors, protein plaque can start developing in the brain. This plaque can disrupt the signaling between brain cells and can even lead to neurodegenerative conditions. Luteolin helps neurons stay healthy by reducing the formation of amyloid plaque in the brain.

It is true that higher testosterone will naturally make you feel better and more confident. But luteolin takes this a step further by boosting your mood directly too.

Centrapeak Stack Strategy: Luteolin + Ashwagandha for Optimized Hormones

Luteolin is often linked to estrogen-blocking benefits in men, but may also be of help towards combating stress and mood swings.

When you’re under stress, your body is secreting a lot of cortisol.

This chief stress hormone inhibits testosterone production, which means that if you’re chronically stressed, your T levels could plummet far below the optimal range. Not to forget that low T levels also link to excess weight gain, low energy, and lack of motivation.

Thankfully, Centrapeak offers a solution in combining luteolin with Ashwagandha – found in Testo Lab Pro.

While luteolin boosts mood by raising GABA levels and affecting the hippocampus, Ashwagandha attacks stress right at the root – killing excess cortisol production.

Clinical research shows that Ashwagandha can reduce cortisol by as much as 30%. (19)

  • Together in Centrapeak, the ingredients luteolin and Ashwagandha work to inhibit stress response and give your testosterone the space to thrive – bringing you back to your peak.


  1. Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. (source)
  2. Natural Products as Aromatase Inhibitors. (source)
  3. Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). (source)
  4. Luteolin, a flavonoid with potentials for cancer prevention and therapy. (source)
  5. Dietary flavonoids and cancer risk: evidence from human population studies. (source)
  6. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. (source)
  7. Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. (source)
  8. Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress. (source)
  9. Identification of the Flavonoid Luteolin as a Repressor of the Transcription Factor Hepatocyte Nuclear Factor 4α*. (source)
  10. Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-A(y) mice. (source)
  11. Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice. (source)
  12. Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor. (source)
  13. Antidepressant Flavonoids and Their Relationship with Oxidative Stress. (source)
  14. Luteolin Inhibits Fibrillary β-Amyloid1–40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways. (source)
  15. Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats. (source)
  16. Luteolin Induces microRNA-132 Expression and Modulates Neurite Outgrowth in PC12 Cells. (source)
  17. Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression. (source)
  18. The Flavonoid Luteolin, but Not Luteolin-7-O-Glucoside, Prevents a Transthyretin Mediated Toxic Response. (source)
  19. A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. (source)

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